Molecular Bioenergetics

The Molecular Bioenergetics laboratories in the Department of Neurology have two main goals: First, to understand the biogenesis of human mitochondria and its regulation and how these processes influence human neuromuscular and neurodegenerative disorders. Second, we are interested in understanding the molecular pathogenesis of mutations in mitochondrial DNA and nDNA that impact mitochondrial function. We are also actively pursuing novel approaches to therapy. These mutations have been associated with devastating clinical syndromes like seizures, strokes, muscle weakness, diabetes and others. For this purposes we use mammalian cell culture, yeast and genetically modified mouse models.

To learn more about the Molecular Biogenetics Laboratories, click on the specific area of interest below: