Clinical Specialties : Stroke Division

Stroke Division Research

The Stroke faculty conducts cutting edge research to address a variety of cerebrovascular diseases. The division is actively enrolling patients in acute stroke treatment, stroke prevention and stroke recovery trials, and has special interest in stroke in minorities.

We are proud to announce that we are a member of the NIH StrokeNet Trials Network.

What is StrokeNet?

The National Institutes of Health created StrokeNet to conduct cutting-edge novel studies in acute treatment, prevention and recovery of Stroke, a consortium of 25 regional centers across the US, involving over 200 hospitals. The network collaborates to create, evaluate and prioritize novel ideas in the pipeline, rapidly complete these studies through expedited regulatory processes to bring needed treatments that will impact stroke care to the clinical arena, and to train the next generation of stroke researchers. It is anticipated that all Stroke studies funded by the National Institutes of Health will be conducted only at StrokeNet sites.

In collaboration with the University of Miami, we have formed a regional consortium in Florida as one of the 25 Regional Networks for StrokeNet and the only one in Florida. It includes acute care, pediatric and rehabilitation hospitals that leverage academic-private-community partnerships.

Our currently enrolling research includes:

  • MyRIAD: This study investigates the possible causes of stroke or TIA in individuals that have a narrowed brain artery (Intracranial Atherosclerotic Disease). It is funded by the NIH/NINDS.
  • ERICH: This prospective observational study aims to understand ethnic and racial differences in intracranial hemorrhage. It is funded by the NIH/NINDS.
  • PRISMS: This trial evaluates the efficacy and safety of the drug alteplase (IV-tPA) in patients that suffered a mild, non-disabling stroke. Funded by Genentech, Inc.
  • iDEF: Examines the effects of the study drug deferoxamine on Intracerebral Hemorrhage (ICH) with the purpose to learn more about the safety of this investigational drug to remove iron from the brain after a brain hemorrhage. Funded by NIH/NINDS.
  • RESPECT-ESUS: Compares the effectiveness and safety of the oral anticoagulant dabigatran exilate compared to aspirin in patients with Embolic Stroke of Undetermined Source. Funded by Boehringer Ingelheim.
  • CREST-2: Compares carotid revascularization plus intensive medical management vs. intensive medical management alone in patients with asymptomatic high-grade carotid stenosis. Patients will be randomized in a 1:1 ratio to endarterectomy vs. no endarterectomy and the other study group will randomize patients in a 1:1 ratio to carotid stenting with embolic protection vs. no stenting. All study patients will receive medical management. Funded by NIH/NINDS.